[AZKen]

Yes. There can be "always-on" fuses and fuses that are turned on by the ignition switch. Possible examples: Headlight switch, horn, lighter, hazard, dome, brake lights...... Just see what operates with switch off to confirm.
Many fuse panels have a split hot bar. One switched, one not.
Some of the items, I list, have a direct hot wire to them, like the headlight switch. That switch can have it's own fuse. The GMC fuse philosophy could have changed with the years. The wiring diagrams are VERY hard to read in the area of fuse panel. Can't exactly see what is a switched fuse and what is not. So a little time spent on testing will tell the tale.
You did not mention what fuses you are talking about and if you tested each and every one.
Also, advise if you have just done some wiring.